SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention

• Piera Calamita ,

  * E-mail: biffo@ingm.org (SB); calamita@ingm.org (PC)

  Affiliation INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy

  http://orcid.org/0000-0002-3780-1050

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• Annarita Miluzio,

  Affiliation INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy

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• Arianna Russo,

  Affiliations INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy, DiSIT, University of Eastern Piedmont, Alessandria, Italy

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• Elisa Pesce,

  Affiliation INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy

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• Sara Ricciardi,

  Affiliation INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy

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• Farhat Khanim,

  Affiliation School of Biosciences, University of Birmingham Edgbaston Birmingham, United Kingdom

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• Cristina Cheroni,

  Affiliation INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy

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• Roberta Alfieri,

  Affiliation INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy

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• Marilena Mancino,

  Affiliation INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy

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• Chiara Gorrini,

  Affiliations Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Grazisa Rossetti,

  Affiliation INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy

  http://orcid.org/0000-0001-6361-311X

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• Ivana Peluso,

  Affiliation Telethon Institute of Genetics and Medicine (TIGEM)-Fondazione Telethon, Pozzuoli, Italy

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• Massimiliano Pagani,

  Affiliations INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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• Diego L. Medina,

  Affiliation Telethon Institute of Genetics and Medicine (TIGEM)-Fondazione Telethon, Pozzuoli, Italy

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• Johanna Rommens,

  Affiliation SickKids Children Hospital, Toronto, Ontario, Canada

  http://orcid.org/0000-0001-8732-825X

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•  [ ... ],
• Stefano Biffo

  * E-mail: biffo@ingm.org (SB); calamita@ingm.org (PC)

  Affiliations INGM, National Institute of Molecular Genetics, “Romeo ed Enrica Invernizzi”, Milan, Italy, DBS, Università degli Studi di Milano, Milan, Italy

  http://orcid.org/0000-0002-3780-1050

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