Shared Information between Residues Is Sufficient to Detect Pairwise Epistasis in a Protein

Open Access

Aditi Gupta,

Affiliation Center for Infectious Diseases, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
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Christoph Adami

* E-mail: adami@msu.edu

Affiliations Department of Microbiology & Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America, BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, Michigan, United States of America

http://orcid.org/0000-0002-2915-9504

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Fitness epistasis
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Entropy
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Genomics
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Information entropy
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Molecular evolution
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Mutation
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Protein interactions
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