Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception

• Deborah Chiabrando ,

  * E-mail: deborah.chiabrando@unito.it(DC); emanuela.tolosano@unito.it(ET); ikurth@ukaachen.de(IK)

  Affiliation Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy

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• Marco Castori,

  Affiliation Unit of Medical Genetics, Department of Molecular Medicine, Sapienza University, San Camillo-Forlanini Hospital, Rome, Italy

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• Maja di Rocco,

  Affiliation Unit of Rare Diseases, Department of Pediatrics, Gaslini Institute, Genoa, Italy

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• Martin Ungelenk,

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Sebastian Gießelmann,

  Affiliations Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany, Institute of Human Genetics, Uniklinik RWTH Aachen, Aachen, Germany

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• Matteo Di Capua,

  Affiliation Unit of Neurophysiopathology, Department of Neuroscience, Bambino Gesù Children's Hospital, Rome, Italy

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• Annalisa Madeo,

  Affiliation Unit of Rare Diseases, Department of Pediatrics, Gaslini Institute, Genoa, Italy

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• Paola Grammatico,

  Affiliation Unit of Medical Genetics, Department of Molecular Medicine, Sapienza University, San Camillo-Forlanini Hospital, Rome, Italy

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• Sophie Bartsch,

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

  http://orcid.org/0000-0001-8080-9480

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• Christian A. Hübner,

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Fiorella Altruda,

  Affiliation Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy

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• Lorenzo Silengo,

  Affiliation Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy

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• Emanuela Tolosano ,

  * E-mail: deborah.chiabrando@unito.it(DC); emanuela.tolosano@unito.it(ET); ikurth@ukaachen.de(IK)

  ¶‡ ET and IK are joint last authors on this work.

  Affiliation Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy

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• Ingo Kurth

  * E-mail: deborah.chiabrando@unito.it(DC); emanuela.tolosano@unito.it(ET); ikurth@ukaachen.de(IK)

  ¶‡ ET and IK are joint last authors on this work.

  Affiliations Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany, Institute of Human Genetics, Uniklinik RWTH Aachen, Aachen, Germany

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