Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling

Janet Ugolino; Yon Ju Ji; Karen Conchina; Justin Chu; Raja Sekhar Nirujogi; Akhilesh Pandey; Nathan R. Brady; Anne Hamacher-Brady; Jiou Wang

doi:10.1371/journal.pgen.1006443

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Open Access

Peer-reviewed

Research Article

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling

Janet Ugolino ,

Contributed equally to this work with: Janet Ugolino, Yon Ju Ji

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, and Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Yon Ju Ji ,

Contributed equally to this work with: Janet Ugolino, Yon Ju Ji

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, and Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Karen Conchina,

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, and Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Justin Chu,

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, and Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Raja Sekhar Nirujogi,

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
⨯
Akhilesh Pandey,

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

http://orcid.org/0000-0001-9943-6127

⨯
Nathan R. Brady,

Affiliation Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Maryland, United States of America
⨯
Anne Hamacher-Brady,

Affiliation Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Maryland, United States of America
⨯
Jiou Wang

* E-mail: jiouw@jhu.edu

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, and Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling

Janet Ugolino,
Yon Ju Ji,
Karen Conchina,
Justin Chu,
Raja Sekhar Nirujogi,
Akhilesh Pandey,
Nathan R. Brady,
Anne Hamacher-Brady,
Jiou Wang

Published: November 22, 2016
https://doi.org/10.1371/journal.pgen.1006443

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