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Open Access
Peer-reviewed
Research Article
The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts
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Natalie Saini,
Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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Steven A. Roberts,
Affiliation School of Molecular Biosciences, Washington State University, Pullman, Washington, United States Of America
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Leszek J. Klimczak,
Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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Kin Chan,
Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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Sara A. Grimm,
Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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Shuangshuang Dai,
Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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David C. Fargo,
Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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Jayne C. Boyer,
Affiliation Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, North Carolina, United States Of America
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William K. Kaufmann,
Affiliation Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, United States Of America
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Jack A. Taylor,
Affiliation Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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Eunjung Lee,
Affiliations Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States Of America, Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, United States Of America
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Isidro Cortes-Ciriano,
Affiliation Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States Of America
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Peter J. Park,
Affiliations Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States Of America, Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, United States Of America
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Shepherd H. Schurman,
Affiliation Clinical Research Unit, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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Ewa P. Malc,
Affiliation Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States Of America
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Piotr A. Mieczkowski,
Affiliation Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States Of America
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Dmitry A. Gordenin
* E-mail: gordenin@niehs.nih.gov
Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America
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The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts
- Natalie Saini,
- Steven A. Roberts,
- Leszek J. Klimczak,
- Kin Chan,
- Sara A. Grimm,
- Shuangshuang Dai,
- David C. Fargo,
- Jayne C. Boyer,
- William K. Kaufmann,
- Jack A. Taylor
- Published: October 27, 2016
- https://doi.org/10.1371/journal.pgen.1006385