High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines

Ireos Filipuzzi; Simona Cotesta; Francesca Perruccio; Britta Knapp; Yue Fu; Christian Studer; Verena Pries; Ralph Riedl; Stephen B. Helliwell; Katarina T. Petrovic; N. Rao Movva; Dominique Sanglard; Jianshi Tao; Dominic Hoepfner

doi:10.1371/journal.pgen.1006374

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Open Access

Peer-reviewed

Research Article

High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines

Ireos Filipuzzi ,

* E-mail: ireos.filipuzzi@novartis.com

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland

http://orcid.org/0000-0002-2493-6183

⨯
Simona Cotesta,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
Francesca Perruccio,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
Britta Knapp,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
Yue Fu,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Christian Studer,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
Verena Pries,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
Ralph Riedl,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
Stephen B. Helliwell,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
Katarina T. Petrovic,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
N. Rao Movva,

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯
Dominique Sanglard,

Affiliation Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland
⨯
Jianshi Tao,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Dominic Hoepfner

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland
⨯

High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines

Ireos Filipuzzi,
Simona Cotesta,
Francesca Perruccio,
Britta Knapp,
Yue Fu,
Christian Studer,
Verena Pries,
Ralph Riedl,
Stephen B. Helliwell,
Katarina T. Petrovic

Published: November 17, 2016
https://doi.org/10.1371/journal.pgen.1006374

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Cryptococcus neoformans
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Saccharomyces cerevisiae
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Lipids
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Antifungals
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