Directed Evolution Reveals Unexpected Epistatic Interactions That Alter Metabolic Regulation and Enable Anaerobic Xylose Use by Saccharomyces cerevisiae

• Trey K. Sato ,

  * E-mail: tksato@glbrc.wisc.edu (TKS); agasch@wisc.edu (APG); landick@wisc.edu (RL)

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-6592-9337

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• Mary Tremaine,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Lucas S. Parreiras,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-6156-4780

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• Alexander S. Hebert,

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Kevin S. Myers,

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Alan J. Higbee,

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-9379-8362

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• Maria Sardi,

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Sean J. McIlwain,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0002-3820-8400

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• Irene M. Ong,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-5968-9437

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• Rebecca J. Breuer,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-6727-3378

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• Ragothaman Avanasi Narasimhan,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-8673-4504

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• Mick A. McGee,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Quinn Dickinson,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Alex La Reau,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-7750-6091

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• Dan Xie,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0002-7335-3726

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• Mingyuan Tian,

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0002-6518-9540

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• Jennifer L. Reed,

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Yaoping Zhang,

  Affiliation DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Joshua J. Coon,

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Chris Todd Hittinger,

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Wisconsin Energy Institute, J.F. Crow Institute for the Study of Evolution, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Audrey P. Gasch ,

  * E-mail: tksato@glbrc.wisc.edu (TKS); agasch@wisc.edu (APG); landick@wisc.edu (RL)

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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•  [ ... ],
• Robert Landick

  * E-mail: tksato@glbrc.wisc.edu (TKS); agasch@wisc.edu (APG); landick@wisc.edu (RL)

  Affiliations DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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