No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

• Emma C. Johnson ,

  * E-mail: Emma.C.Johnson@colorado.edu; matthew.c.keller@gmail.com.

  Affiliations Department of Psychology and Neuroscience, University of Colorado at Boulder, United States of America, Institute for Behavioral Genetics, University of Colorado at Boulder, United States of America

  http://orcid.org/0000-0003-0394-777X

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• Douglas W. Bjelland,

  Affiliation Institute for Behavioral Genetics, University of Colorado at Boulder, United States of America

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• Daniel P. Howrigan,

  Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, United States of America

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• Abdel Abdellaoui,

  Affiliation Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands

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• Gerome Breen,

  Affiliation IDepartment of Social Genetic and Developmental Psychiatry, King’s College London, London, United Kingdom

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• Anders Borglum,

  Affiliations The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark, Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark, Department of Biomedicine, Aarhus University, Aarhus, Denmark, Department P, Aarhus University Hospital, Risskov, Denmark

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• Sven Cichon,

  Affiliations Department of Genomics, Life and Brain Center, University of Bonn, Germany, Division of Medical Genetics, Department of Biomedicine, University Basel, Basel, Switzerland, Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organisation of the Brain, Genomic Imaging, Research Centre Juelich, Juelich, Germany, Institute of Human Genetics, University of Bonn, Bonn, Germany

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• Franziska Degenhardt,

  Affiliations Department of Genomics, Life and Brain Center, University of Bonn, Germany, Institute of Human Genetics, University of Bonn, Bonn, Germany

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• Andreas J. Forstner,

  Affiliations Department of Genomics, Life and Brain Center, University of Bonn, Germany, Institute of Human Genetics, University of Bonn, Bonn, Germany

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• Josef Frank,

  Affiliation Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany

  http://orcid.org/0000-0003-3578-7053

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• Giulio Genovese,

  Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

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• Stefanie Heilmann-Heimbach,

  Affiliations Department of Genomics, Life and Brain Center, University of Bonn, Germany, Institute of Human Genetics, University of Bonn, Bonn, Germany

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• Stefan Herms,

  Affiliations Department of Genomics, Life and Brain Center, University of Bonn, Germany, Division of Medical Genetics, Department of Biomedicine, University Basel, Basel, Switzerland, Institute of Human Genetics, University of Bonn, Bonn, Germany

  http://orcid.org/0000-0002-2786-8200

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• Per Hoffman,

  Affiliations Department of Genomics, Life and Brain Center, University of Bonn, Germany, Division of Medical Genetics, Department of Biomedicine, University Basel, Basel, Switzerland, Institute of Human Genetics, University of Bonn, Bonn, Germany

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• Wolfgang Maier,

  Affiliation Department of Psychiatry, University of Bonn, Bonn, Germany

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• Manuel Mattheisen,

  Affiliation Institute of Human Genetics, University of Bonn, Bonn, Germany

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• Derek Morris,

  Affiliation Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, St. James's Hospital, Ireland

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• Bryan Mowry,

  Affiliations Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health, Wacol, Australia, Department of Psychiatry, University of Queensland, Brisbane, Australia

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• Betram Müller-Mhysok,

  Affiliations Max Planck Institute of Psychiatry, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, University of Liverpool, Institute of Translational Medicine, Liverpool, United Kingdom

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• Benjamin Neale,

  Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, United States of America

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• Igor Nenadic,

  Affiliation Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany

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• Markus M. Nöthen,

  Affiliations Department of Genomics, Life and Brain Center, University of Bonn, Germany, Institute of Human Genetics, University of Bonn, Bonn, Germany

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• Colm O’Dushlaine,

  Affiliation Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland

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• Marcella Rietschel,

  Affiliation Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany

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• Douglas M. Ruderfer,

  Affiliation Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

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• Dan Rujescu,

  Affiliations Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany, Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany

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• Thomas G. Schulze,

  Affiliation Institute for Psychiatric Phenomics and Genomics (IPPG), Ludwig-Maximilians-University, Munich, Germany

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• Matthew A. Simonson,

  Affiliation Mayo Clinic, Department of Health Sciences, Division of Biomedical Statistics and Informatics, Rochester, Minnesota, United States of America

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• Eli Stahl,

  Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

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• Jana Strohmaier,

  Affiliation Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany

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• Stephanie H. Witt,

  Affiliation Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany

  http://orcid.org/0000-0002-1571-1468

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• Schizophrenia Working Group of the Psychiatric Genomics Consortium ,

  ¶¶Membership of the Schizophrenia Working Group of the Psychiatric Genomics Consortium is provided in the acknowledgments.

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• Patrick F. Sullivan,

  Affiliations Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden, Department of Genetics, University of North Carolina, Chapel Hill, NC, United States of America, Department of Psychiatry, University of North Carolina, Chapel Hill, NC, United States of America

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•  [ ... ],
• Matthew C. Keller

  * E-mail: Emma.C.Johnson@colorado.edu; matthew.c.keller@gmail.com.

  Affiliations Department of Psychology and Neuroscience, University of Colorado at Boulder, United States of America, Institute for Behavioral Genetics, University of Colorado at Boulder, United States of America

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