Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection

• Athma A. Pai ,

  Contributed equally to this work with: Athma A. Pai, Golshid Baharian

  * E-mail: athma@mit.edu (AAP); luis.barreiro@umontreal.ca (LBB)

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

  http://orcid.org/0000-0002-7995-9948

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• Golshid Baharian ,

  Contributed equally to this work with: Athma A. Pai, Golshid Baharian

  Affiliations Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada, Sainte-Justine Hospital Research Centre, Montreal, QC, Canada

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• Ariane Pagé Sabourin,

  Affiliation Sainte-Justine Hospital Research Centre, Montreal, QC, Canada

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• Jessica F. Brinkworth,

  Affiliations Sainte-Justine Hospital Research Centre, Montreal, QC, Canada, Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, QC, Canada, Department of Anthropology, University of Illinois, Urbana-Champaign, IL, USA

  http://orcid.org/0000-0002-9087-3328

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• Yohann Nédélec,

  Affiliations Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada, Sainte-Justine Hospital Research Centre, Montreal, QC, Canada

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• Joseph W. Foley,

  Affiliation Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA

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• Jean-Christophe Grenier,

  Affiliation Sainte-Justine Hospital Research Centre, Montreal, QC, Canada

  http://orcid.org/0000-0001-7937-5160

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• Katherine J. Siddle,

  Affiliation Department of Organismic and Evolutionary Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA, USA

  http://orcid.org/0000-0002-1799-7295

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• Anne Dumaine,

  Affiliation Sainte-Justine Hospital Research Centre, Montreal, QC, Canada

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• Vania Yotova,

  Affiliation Sainte-Justine Hospital Research Centre, Montreal, QC, Canada

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• Zachary P. Johnson,

  Affiliations Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA

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• Robert E. Lanford,

  Affiliation Texas Biomedical Research Institute, Southwest National Primate Research Center, San Antonio, TX, USA

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• Christopher B. Burge,

  Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

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• Luis B. Barreiro

  * E-mail: athma@mit.edu (AAP); luis.barreiro@umontreal.ca (LBB)

  Affiliations Sainte-Justine Hospital Research Centre, Montreal, QC, Canada, Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, QC, Canada

  http://orcid.org/0000-0001-9456-367X

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