Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease

• Christoph Preuss ,

  Contributed equally to this work with: Christoph Preuss, Melanie Capredon, Florian Wünnemann

  Affiliation Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Québec, Canada

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• Melanie Capredon ,

  Contributed equally to this work with: Christoph Preuss, Melanie Capredon, Florian Wünnemann

  Affiliation Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Québec, Canada

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• Florian Wünnemann ,

  Contributed equally to this work with: Christoph Preuss, Melanie Capredon, Florian Wünnemann

  Affiliations Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Québec, Canada, Faculty of Biology, University of Muenster, Muenster, Germany

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• Philippe Chetaille,

  Affiliation Department of Pediatrics, Centre Mère Enfants Soleil, Centre Hospitalier de l'Université (CHU) de Québec, Quebec City, Québec, Canada

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• Andrea Prince,

  Affiliation Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Québec, Canada

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• Beatrice Godard,

  Affiliation Omics-Ethics Research Group, Research Institute of Public Health, Université de Montréal, Montréal Québec, Canada

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• Severine Leclerc,

  Affiliation Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Québec, Canada

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• Nara Sobreira,

  Affiliation McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Hua Ling,

  Affiliation McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Philip Awadalla,

  Affiliation Ontario Institute for Cancer Research, Toronto, Ontario, Canada

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• Maryse Thibeault,

  Affiliation Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Québec, Canada

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• Paul Khairy,

  Affiliation Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada

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• MIBAVA Leducq consortium,

  Affiliation Membership of the MIBAVA Leducq consortium is provided in the Acknowledgements

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• Mark E. Samuels,

  Affiliations Centre de Recherche CHU Sainte Justine, Université de Montreal, Montréal, Québec, Canada, Department of Medicine, Université de Montreal, Montréal, Québec, Canada

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• Gregor Andelfinger

  * E-mail: gregor.andelfinger@recherche-ste-justine.qc.ca

  Affiliation Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Québec, Canada

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