Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

Staci L. Haney; G. Michael Upchurch; Jana Opavska; David Klinkebiel; Ryan A. Hlady; Sohini Roy; Samikshan Dutta; Kaustubh Datta; Rene Opavsky

doi:10.1371/journal.pgen.1006334

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Open Access

Peer-reviewed

Research Article

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

Staci L. Haney ,

Contributed equally to this work with: Staci L. Haney, G. Michael Upchurch

Affiliation Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
G. Michael Upchurch ,

Contributed equally to this work with: Staci L. Haney, G. Michael Upchurch

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

http://orcid.org/0000-0003-4193-0733

⨯
Jana Opavska,

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
David Klinkebiel,

Affiliation Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Ryan A. Hlady,

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America

http://orcid.org/0000-0002-2829-4237

⨯
Sohini Roy,

Affiliation Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Samikshan Dutta,

Affiliation Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Kaustubh Datta,

Affiliation Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Rene Opavsky

* E-mail: ropavsky@unmc.edu

Affiliations Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Leukemia and Lymphoma Research, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

Staci L. Haney,
G. Michael Upchurch,
Jana Opavska,
David Klinkebiel,
Ryan A. Hlady,
Sohini Roy,
Samikshan Dutta,
Kaustubh Datta,
Rene Opavsky

Published: September 30, 2016
https://doi.org/10.1371/journal.pgen.1006334

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DNA methylation
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Cytotoxic T cells
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T cells
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Gene expression
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Lymphoma
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Tumor suppressor genes
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