RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

Mrinmoyee Majumder; Reniqua House; Nallasivam Palanisamy; Shuo Qie; Terrence A. Day; David Neskey; J. Alan Diehl; Viswanathan Palanisamy

doi:10.1371/journal.pgen.1006306

Loading metrics

Open Access

Peer-reviewed

Research Article

RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

Mrinmoyee Majumder,

Affiliation Department of Oral Health Sciences and Center for Oral Health Research, College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Reniqua House,

Affiliation Department of Oral Health Sciences and Center for Oral Health Research, College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Nallasivam Palanisamy,

Affiliation Department of Urology, Henry Ford Health System, Vattikuti Urology Institute, Detroit, Michigan, United States of America
⨯
Shuo Qie,

Affiliation Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Terrence A. Day,

Affiliation Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
David Neskey,

Affiliation Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
J. Alan Diehl,

Affiliation Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Viswanathan Palanisamy

* E-mail: visu@musc.edu

Affiliations Department of Oral Health Sciences and Center for Oral Health Research, College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America, Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

http://orcid.org/0000-0001-5128-2878

⨯

RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

Mrinmoyee Majumder,
Reniqua House,
Nallasivam Palanisamy,
Shuo Qie,
Terrence A. Day,
David Neskey,
J. Alan Diehl,
Viswanathan Palanisamy

Published: September 8, 2016
https://doi.org/10.1371/journal.pgen.1006306

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Telomerase RNA component
Is the Subject Area "Telomerase RNA component" applicable to this article?

Thanks for your feedback.
Senescence
Is the Subject Area "Senescence" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Head and neck cancers
Is the Subject Area "Head and neck cancers" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Luciferase
Is the Subject Area "Luciferase" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.