Functional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native Activity

Open Access

Peer-reviewed

Research Article

Miriam Kaltenbach,

Current address: Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel

Affiliation Michael Smith Laboratories, University of British Columbia, Vancouver, Canada
⨯
Stephane Emond,

Affiliation Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
⨯
Florian Hollfelder,

Affiliation Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

http://orcid.org/0000-0002-1367-6312

⨯
Nobuhiko Tokuriki

* E-mail: tokuriki@msl.ubc.ca

Affiliation Michael Smith Laboratories, University of British Columbia, Vancouver, Canada
⨯

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Point mutation
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Deletion mutation
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Molecular evolution
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Evolutionary genetics
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Substitution mutation
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Hydrolysis
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Sign epistasis
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Enzymes
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