Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans

Vincent Portegijs; Lars-Eric Fielmich; Matilde Galli; Ruben Schmidt; Javier Muñoz; Tim van Mourik; Anna Akhmanova; Albert J. R. Heck; Mike Boxem; Sander van den Heuvel

doi:10.1371/journal.pgen.1006291

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Open Access

Peer-reviewed

Research Article

Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans

Vincent Portegijs,

Affiliation Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯
Lars-Eric Fielmich ,

Contributed equally to this work with: Lars-Eric Fielmich, Matilde Galli

Affiliation Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯
Matilde Galli ,

Contributed equally to this work with: Lars-Eric Fielmich, Matilde Galli

Current address: Hubrecht Institute, Utrecht, The Netherlands,

Affiliation Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯
Ruben Schmidt,

Affiliations Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands, Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands

http://orcid.org/0000-0001-9187-5424

⨯
Javier Muñoz,

Current address: Spanish National Cancer Research Centre (CNIO), ProteoRed-ISCIII, Madrid, Spain

Affiliation Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

http://orcid.org/0000-0003-3288-3496

⨯
Tim van Mourik,

Affiliation Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯
Anna Akhmanova,

Affiliation Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯
Albert J. R. Heck,

Affiliation Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
⨯
Mike Boxem,

Affiliation Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands

http://orcid.org/0000-0003-3966-4173

⨯
Sander van den Heuvel

* E-mail: s.j.l.vandenHeuvel@uu.nl

Affiliation Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯

Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans

Vincent Portegijs,
Lars-Eric Fielmich,
Matilde Galli,
Ruben Schmidt,
Javier Muñoz,
Tim van Mourik,
Anna Akhmanova,
Albert J. R. Heck,
Mike Boxem,
Sander van den Heuvel

Published: October 6, 2016
https://doi.org/10.1371/journal.pgen.1006291

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Dyneins
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Embryos
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RNA interference
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Caenorhabditis elegans
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In vitro kinase assay
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