Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP

Bo Hu; Sezgi Arpag; Xuebao Zhang; Wiebke Möbius; Hauke Werner; Gina Sosinsky; Mark Ellisman; Yang Zhang; Audra Hamilton; Jonathan Chernoff; Jun Li

doi:10.1371/journal.pgen.1006290

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Open Access

Peer-reviewed

Research Article

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP

Bo Hu,

Affiliation Department of Neurology, Center for Human Genetics Research, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Sezgi Arpag,

Affiliation Department of Neurology, Center for Human Genetics Research, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

http://orcid.org/0000-0002-6449-4164

⨯
Xuebao Zhang,

Affiliation Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan, United States of America
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Wiebke Möbius,

Affiliation Center Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), GÖttingen, Germany
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Hauke Werner,

Affiliation Center Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), GÖttingen, Germany
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Gina Sosinsky,

Affiliation National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California, United States of America
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Mark Ellisman,

Affiliation National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California, United States of America
⨯
Yang Zhang,

Affiliation Department of Neurology, Center for Human Genetics Research, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Audra Hamilton,

Affiliation Department of Neurology, Center for Human Genetics Research, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Jonathan Chernoff,

Affiliation Cancer Biology, Fox Chase Cancer Center, Philadelphia, United States of America
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Jun Li

* E-mail: jun.li.2@vanderbilt.edu

Affiliations Department of Neurology, Center for Human Genetics Research, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America
⨯

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP

Bo Hu,
Sezgi Arpag,
Xuebao Zhang,
Wiebke Möbius,
Hauke Werner,
Gina Sosinsky,
Mark Ellisman,
Yang Zhang,
Audra Hamilton,
Jonathan Chernoff

Published: September 1, 2016
https://doi.org/10.1371/journal.pgen.1006290

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