Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

Barbara Mair; Tomasz Konopka; Claudia Kerzendorfer; Katia Sleiman; Sejla Salic; Violeta Serra; Markus K. Muellner; Vasiliki Theodorou; Sebastian M. B. Nijman

doi:10.1371/journal.pgen.1006279

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Open Access

Peer-reviewed

Research Article

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

Barbara Mair,

Affiliations CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

http://orcid.org/0000-0001-6982-2529

⨯
Tomasz Konopka,

Affiliations Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

http://orcid.org/0000-0003-3042-4712

⨯
Claudia Kerzendorfer,

Affiliation CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
⨯
Katia Sleiman,

Affiliation CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

http://orcid.org/0000-0001-5808-1913

⨯
Sejla Salic,

Affiliations Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Violeta Serra,

Affiliation Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain
⨯
Markus K. Muellner,

Current address: PhoreMost Ltd, Babraham Science Park, Cambridge, United Kingdom

Affiliation CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
⨯
Vasiliki Theodorou,

Affiliation Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology—Hellas, Heraklion, Crete, Greece

http://orcid.org/0000-0003-1614-700X

⨯
Sebastian M. B. Nijman

* E-mail: sebastian.nijman@ludwig.ox.ac.uk

Affiliations CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

Barbara Mair,
Tomasz Konopka,
Claudia Kerzendorfer,
Katia Sleiman,
Sejla Salic,
Violeta Serra,
Markus K. Muellner,
Vasiliki Theodorou,
Sebastian M. B. Nijman

Published: September 2, 2016
https://doi.org/10.1371/journal.pgen.1006279

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Breast cancer
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