Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling

Hua Shen; Xiaobo Yu; Fengming Yang; Zhihua Zhang; Jianxin Shen; Jin Sun; Swati Choksi; Siriporn Jitkaew; Yongqian Shu

doi:10.1371/journal.pgen.1006244

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Open Access

Peer-reviewed

Research Article

Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling

Hua Shen,

Affiliations Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Xiaobo Yu,

Affiliation Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China
⨯
Fengming Yang,

Affiliations Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Zhihua Zhang,

Affiliation Department of Respiration, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, China
⨯
Jianxin Shen,

Affiliation Department of Clinical Laborotory, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, China
⨯
Jin Sun,

Affiliation Department of Nuclear Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Swati Choksi,

Affiliation National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Siriporn Jitkaew,

Affiliation Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand
⨯
Yongqian Shu

* E-mail: shuyongqian1999@126.com

Affiliations Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯

Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling

Hua Shen,
Xiaobo Yu,
Fengming Yang,
Zhihua Zhang,
Jianxin Shen,
Jin Sun,
Swati Choksi,
Siriporn Jitkaew,
Yongqian Shu

Published: August 19, 2016
https://doi.org/10.1371/journal.pgen.1006244

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