Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters

Christopher A. Lavender; Kimberly R. Cannady; Jackson A. Hoffman; Kevin W. Trotter; Daniel A. Gilchrist; Brian D. Bennett; Adam B. Burkholder; Craig J. Burd; David C. Fargo; Trevor K. Archer

doi:10.1371/journal.pgen.1006224

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Open Access

Peer-reviewed

Research Article

Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters

Christopher A. Lavender,

Affiliations Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America, Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Kimberly R. Cannady,

Affiliation Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

http://orcid.org/0000-0003-4672-834X

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Jackson A. Hoffman,

Affiliation Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Kevin W. Trotter,

Affiliation Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Daniel A. Gilchrist,

Current Address: National Human Genome Research Institute, Bethesda, Maryland, United States of America

Affiliation Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Brian D. Bennett,

Affiliation Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Adam B. Burkholder,

Affiliation Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Craig J. Burd,

Affiliations Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, United States of America, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America

http://orcid.org/0000-0002-6899-6751

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David C. Fargo ,

* E-mail: fargod@niehs.nih.gov (DCF); archer1@niehs.nih.gov (TKA)

Affiliation Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Trevor K. Archer

* E-mail: fargod@niehs.nih.gov (DCF); archer1@niehs.nih.gov (TKA)

Affiliation Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
⨯

Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters

Christopher A. Lavender,
Kimberly R. Cannady,
Jackson A. Hoffman,
Kevin W. Trotter,
Daniel A. Gilchrist,
Brian D. Bennett,
Adam B. Burkholder,
Craig J. Burd,
David C. Fargo,
Trevor K. Archer

Published: August 3, 2016
https://doi.org/10.1371/journal.pgen.1006224

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DNA transcription
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Nucleosomes
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Sequence motif analysis
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Chromatin
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Transcription factors
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Gene expression
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Sequence alignment
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