A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

Sahar Kassem; Guillaume Gaud; Isabelle Bernard; Mehdi Benamar; Anne S. Dejean; Roland Liblau; Gilbert J. Fournié; Céline Colacios; Bernard Malissen; Abdelhadi Saoudi

doi:10.1371/journal.pgen.1006185

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Peer-reviewed

Research Article

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

Sahar Kassem,

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
⨯
Guillaume Gaud,

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France

http://orcid.org/0000-0001-8415-854X

⨯
Isabelle Bernard,

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
⨯
Mehdi Benamar,

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France

http://orcid.org/0000-0003-1532-8642

⨯
Anne S. Dejean,

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
⨯
Roland Liblau,

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
⨯
Gilbert J. Fournié,

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
⨯
Céline Colacios,

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
⨯
Bernard Malissen ,

Contributed equally to this work with: Bernard Malissen, Abdelhadi Saoudi

Affiliations Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, Marseille, France, Centre d’Immunophénomique, Aix Marseille Université UM2, Inserm US012, CNRS UMS3367, 13288 Marseille, France
⨯
Abdelhadi Saoudi

Contributed equally to this work with: Bernard Malissen, Abdelhadi Saoudi

* E-mail: abdelhadi.saoudi@inserm.fr

Affiliations UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
⨯

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

Sahar Kassem,
Guillaume Gaud,
Isabelle Bernard,
Mehdi Benamar,
Anne S. Dejean,
Roland Liblau,
Gilbert J. Fournié,
Céline Colacios,
Bernard Malissen,
Abdelhadi Saoudi

Published: July 20, 2016
https://doi.org/10.1371/journal.pgen.1006185

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