Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington’s Disease

Joseph R. Scarpa; Peng Jiang; Bojan Losic; Ben Readhead; Vance D. Gao; Joel T. Dudley; Martha H. Vitaterna; Fred W. Turek; Andrew Kasarskis

doi:10.1371/journal.pgen.1006137

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Peer-reviewed

Research Article

Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington’s Disease

Joseph R. Scarpa ,

* E-mail: joseph.scarpa@icahn.mssm.edu

Affiliation Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Peng Jiang,

Affiliation Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America
⨯
Bojan Losic,

Affiliation Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Ben Readhead,

Affiliation Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Vance D. Gao,

Affiliation Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America

http://orcid.org/0000-0003-4492-1154

⨯
Joel T. Dudley,

Affiliation Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Martha H. Vitaterna,

Affiliation Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America
⨯
Fred W. Turek,

Affiliation Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America
⨯
Andrew Kasarskis

Affiliation Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

http://orcid.org/0000-0001-6454-9076

⨯

Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington’s Disease

Joseph R. Scarpa,
Peng Jiang,
Bojan Losic,
Ben Readhead,
Vance D. Gao,
Joel T. Dudley,
Martha H. Vitaterna,
Fred W. Turek,
Andrew Kasarskis

Published: July 8, 2016
https://doi.org/10.1371/journal.pgen.1006137

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