N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy

Xudong Liu; Chuan-En Wang; Yan Hong; Ting Zhao; Guohao Wang; Marta A. Gaertig; Miao Sun; Shihua Li; Xiao-Jiang Li

doi:10.1371/journal.pgen.1006083

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Peer-reviewed

Research Article

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy

Xudong Liu,

Affiliations State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Graduate School of the Chinese Academy of Sciences, Beijing, China
⨯
Chuan-En Wang,

Affiliation Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Yan Hong,

Affiliation Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Ting Zhao,

Affiliation Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Guohao Wang,

Affiliations State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Graduate School of the Chinese Academy of Sciences, Beijing, China
⨯
Marta A. Gaertig,

Affiliation Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Miao Sun,

Affiliation Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Shihua Li ,

* E-mail: sli@emory.edu (SL); xli2@emory.edu (XJL)

Affiliation Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Xiao-Jiang Li

* E-mail: sli@emory.edu (SL); xli2@emory.edu (XJL)

Affiliations State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy

Xudong Liu,
Chuan-En Wang,
Yan Hong,
Ting Zhao,
Guohao Wang,
Marta A. Gaertig,
Miao Sun,
Shihua Li,
Xiao-Jiang Li

Published: May 20, 2016
https://doi.org/10.1371/journal.pgen.1006083

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