Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila

Wenhua Li; Aiyu Yao; Hui Zhi; Kuldeep Kaur; Yong-chuan Zhu; Mingyue Jia; Hui Zhao; Qifu Wang; Shan Jin; Guoli Zhao; Zhi-Qi Xiong; Yong Q. Zhang

doi:10.1371/journal.pgen.1006062

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Open Access

Peer-reviewed

Research Article

Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila

Wenhua Li ,

Contributed equally to this work with: Wenhua Li, Aiyu Yao, Hui Zhi

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Aiyu Yao ,

Contributed equally to this work with: Wenhua Li, Aiyu Yao, Hui Zhi

* E-mail: ayyao@genetics.ac.cn (AY); yqzhang@genetics.ac.cn (YQZ)

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Hui Zhi ,

Contributed equally to this work with: Wenhua Li, Aiyu Yao, Hui Zhi

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Kuldeep Kaur,

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Yong-chuan Zhu,

Affiliation Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Mingyue Jia,

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

http://orcid.org/0000-0003-1291-1111

⨯
Hui Zhao,

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Qifu Wang,

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Shan Jin,

Affiliation College of Life Science, Hubei University, Wuhan, Hubei, China
⨯
Guoli Zhao,

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯
Zhi-Qi Xiong,

Affiliation Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Yong Q. Zhang

* E-mail: ayyao@genetics.ac.cn (AY); yqzhang@genetics.ac.cn (YQZ)

Affiliation Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
⨯

Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila

Wenhua Li,
Aiyu Yao,
Hui Zhi,
Kuldeep Kaur,
Yong-chuan Zhu,
Mingyue Jia,
Hui Zhao,
Qifu Wang,
Shan Jin,
Guoli Zhao

Published: May 27, 2016
https://doi.org/10.1371/journal.pgen.1006062

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BMP signaling
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Synapses
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Larvae
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Ubiquitination
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Drosophila melanogaster
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Immunoprecipitation
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Endocytosis
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Transfection
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