Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

• J. Gustav Smith ,

  * E-mail: gustav.smith@med.lu.se

  Affiliations Department of Cardiology, Department of Clinical Sciences, Lund University, Lund, Sweden, Department of Heart Failure and Valvular Disease, Skåne University Hospital, Lund, Sweden, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research and Cardiovascular Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Clinical Sciences, Lund University, Malmö, Sweden

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• Janine F. Felix,

  Affiliations Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Aging (NGI-NCHA), The Netherlands Genomics Initiative, Leiden, the Netherlands

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• Alanna C. Morrison,

  Affiliation Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Andreas Kalogeropoulos,

  Affiliation Emory Clinical Cardiovascular Research Institute, Emory University, Atlanta, Georgia, United States of America

  http://orcid.org/0000-0002-1284-429X

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• Stella Trompet,

  Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands

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• Jemma B. Wilk,

  Affiliation Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Olof Gidlöf,

  Affiliation Department of Cardiology, Department of Clinical Sciences, Lund University, Lund, Sweden

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• Xinchen Wang,

  Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-5198-6581

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• Michael Morley,

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Michael Mendelson,

  Affiliations The Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, National Heart, Lund and Blood Institute, Bethesda, Maryland, United States of America, Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0001-7590-3958

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• Roby Joehanes,

  Affiliations The Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, National Heart, Lund and Blood Institute, Bethesda, Maryland, United States of America

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• Symen Ligthart,

  Affiliation Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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• Xiaoyin Shan,

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Joshua C. Bis,

  Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

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• Ying A. Wang,

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0001-8863-2376

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• Marketa Sjögren,

  Affiliation Department of Clinical Sciences, Lund University, Malmö, Sweden

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• Julius Ngwa,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• Jeffrey Brandimarto,

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  http://orcid.org/0000-0002-9348-2349

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• David J. Stott,

  Affiliation Academic Section of Geriatric Medicine, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom

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• David Aguilar,

  Affiliation Baylor College of Medicine, Houston, Texas, United States of America

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• Kenneth M. Rice,

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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• Howard D. Sesso,

  Affiliation Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Serkalem Demissie,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• Brendan M. Buckley,

  Affiliation Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland

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• Kent D. Taylor,

  Affiliation Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, United States of America

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• Ian Ford,

  Affiliation Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom

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• Chen Yao,

  Affiliations The Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, National Heart, Lund and Blood Institute, Bethesda, Maryland, United States of America

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• Chunyu Liu,

  Affiliations The Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, National Heart, Lund and Blood Institute, Bethesda, Maryland, United States of America

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• CHARGE-SCD consortium ,

  ¶Membership of consortia are listed in the Supporting Information.

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• EchoGen consortium ,

  ¶Membership of consortia are listed in the Supporting Information.

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• QT-IGC consortium ,

  ¶Membership of consortia are listed in the Supporting Information.

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• CHARGE-QRS consortium ,

  ¶Membership of consortia are listed in the Supporting Information.

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• Nona Sotoodehnia,

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Pim van der Harst,

  Affiliation Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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• Bruno H. Ch. Stricker,

  Affiliations Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Inspectorate for Health Care, The Hague, the Netherlands, Department of Medical Informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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• Stephen B. Kritchevsky,

  Affiliation Department of Internal Medicine, Section on Geronotology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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• Yongmei Liu,

  Affiliation Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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• J. Michael Gaziano,

  Affiliation Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Albert Hofman,

  Affiliation Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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• Christine S. Moravec,

  Affiliation Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

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• André G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Aging (NGI-NCHA), The Netherlands Genomics Initiative, Leiden, the Netherlands, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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• Manolis Kellis,

  Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Joyce B. van Meurs,

  Affiliation Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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• Kenneth B. Margulies,

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Abbas Dehghan,

  Affiliation Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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• Daniel Levy,

  Affiliations The Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, National Heart, Lund and Blood Institute, Bethesda, Maryland, United States of America

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• Björn Olde,

  Affiliation Department of Cardiology, Department of Clinical Sciences, Lund University, Lund, Sweden

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• Bruce M. Psaty,

  Affiliations Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

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• L. Adrienne Cupples,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• J. Wouter Jukema,

  Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands, Durrer Center for Cardiogenetic Research, Amsterdam, the Netherlands, Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands

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• Luc Djousse,

  Affiliation Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Oscar H. Franco,

  Affiliations Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Aging (NGI-NCHA), The Netherlands Genomics Initiative, Leiden, the Netherlands

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• Eric Boerwinkle,

  Affiliations Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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• Laurie A. Boyer,

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Christopher Newton-Cheh,

  Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research and Cardiovascular Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Javed Butler,

  Affiliation Emory Clinical Cardiovascular Research Institute, Emory University, Atlanta, Georgia, United States of America

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• Ramachandran S. Vasan,

  Affiliation Departments of Medicine and Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Thomas P. Cappola,

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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•  [ ... ],
• Nicholas L. Smith

  Affiliations Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Seattle Epidemiologic Research and Information Center, Department of Veteran Affairs Office of Research and Development, Seattle, Washington, United States of America

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