Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ

Kay-Marie Lamar; Sasha Bogdanovich; Brandon B. Gardner; Quan Q. Gao; Tamari Miller; Judy U. Earley; Michele Hadhazy; Andy H. Vo; Lisa Wren; Jeffery D. Molkentin; Elizabeth M. McNally

doi:10.1371/journal.pgen.1006019

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Open Access

Peer-reviewed

Research Article

Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ

Kay-Marie Lamar,

Affiliations Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois, United States of America

http://orcid.org/0000-0001-9572-8384

⨯
Sasha Bogdanovich,

Affiliation Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois, United States of America

http://orcid.org/0000-0003-4514-7893

⨯
Brandon B. Gardner,

Affiliation Molecular Pathogenesis and Molecular Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Quan Q. Gao,

Affiliation Committee on Development, Regeneration, and Stem Cell Biology, The University of Chicago, Chicago, Illinois, United States of America
⨯
Tamari Miller,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

http://orcid.org/0000-0001-8629-7973

⨯
Judy U. Earley,

Affiliation Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois, United States of America

http://orcid.org/0000-0002-6872-6516

⨯
Michele Hadhazy,

Affiliation Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois, United States of America
⨯
Andy H. Vo,

Affiliation Committee on Development, Regeneration, and Stem Cell Biology, The University of Chicago, Chicago, Illinois, United States of America
⨯
Lisa Wren,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Jeffery D. Molkentin,

Affiliation Cincinnati Children’s Hospital, Howard Hughes Medicine Institutes, Cincinnati, Ohio, United States of America
⨯
Elizabeth M. McNally

* E-mail: elizabeth.mcnally@northwestern.edu

Affiliation Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois, United States of America
⨯

Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ

Kay-Marie Lamar,
Sasha Bogdanovich,
Brandon B. Gardner,
Quan Q. Gao,
Tamari Miller,
Judy U. Earley,
Michele Hadhazy,
Andy H. Vo,
Lisa Wren,
Jeffery D. Molkentin

Published: May 5, 2016
https://doi.org/10.1371/journal.pgen.1006019

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Skeletal muscles
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Co-immunoprecipitation
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Muscular dystrophies
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