Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress

Therese Wilhelm; Sandrine Ragu; Indiana Magdalou; Christelle Machon; Elodie Dardillac; Hervé Técher; Jérôme Guitton; Michelle Debatisse; Bernard S. Lopez

doi:10.1371/journal.pgen.1006007

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Peer-reviewed

Research Article

Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress

Therese Wilhelm ,

Contributed equally to this work with: Therese Wilhelm, Sandrine Ragu

Current address: Département de Physiologie Cellulaire et Métabolisme, Université de Genève, Geneva, Switzerland

Affiliation CNRS UMR 8200, Gustave Roussy Cancer Institute, Université Paris-Saclay, Team labeled “Ligue 2014”, Villejuif, France
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Sandrine Ragu ,

Contributed equally to this work with: Therese Wilhelm, Sandrine Ragu

Affiliation CNRS UMR 8200, Gustave Roussy Cancer Institute, Université Paris-Saclay, Team labeled “Ligue 2014”, Villejuif, France
⨯
Indiana Magdalou,

Affiliation CNRS UMR 8200, Gustave Roussy Cancer Institute, Université Paris-Saclay, Team labeled “Ligue 2014”, Villejuif, France
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Christelle Machon,

Affiliations Laboratoire de Biochimie et Toxicologie, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France, Laboratoire de Chimie Analytique, Université de Lyon, Université Lyon 1, ISPB Faculté de Pharmacie, Lyon, France
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Elodie Dardillac,

Affiliation CNRS UMR 8200, Gustave Roussy Cancer Institute, Université Paris-Saclay, Team labeled “Ligue 2014”, Villejuif, France
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Hervé Técher,

Affiliation Institut Curie, Centre de Recherche, Paris, France, UPMC Université Paris 06, Paris, France, CNRS UMR 3244, Paris, France
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Jérôme Guitton,

Affiliations Laboratoire de Biochimie et Toxicologie, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France, Laboratoire de Toxicologie, Université Lyon 1, ISPB, Faculté de Pharmacie, Lyon, France
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Michelle Debatisse,

Affiliation Institut Curie, Centre de Recherche, Paris, France, UPMC Université Paris 06, Paris, France, CNRS UMR 3244, Paris, France
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Bernard S. Lopez

* E-mail: Bernard.lopez@gustaveroussy.fr

Affiliation CNRS UMR 8200, Gustave Roussy Cancer Institute, Université Paris-Saclay, Team labeled “Ligue 2014”, Villejuif, France
⨯

Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress

Therese Wilhelm,
Sandrine Ragu,
Indiana Magdalou,
Christelle Machon,
Elodie Dardillac,
Hervé Técher,
Jérôme Guitton,
Michelle Debatisse,
Bernard S. Lopez

Published: May 2, 2016
https://doi.org/10.1371/journal.pgen.1006007

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DNA damage
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Nucleotides
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DNA repair
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