Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients

• Hsin-Chou Yang,

  Affiliations Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, Bioinformatics Program, Taiwan International Graduate Program, Institute of Information Science, Academia Sinica, Taipei, Taiwan, Institute of Public Health, National Yang Ming University, Taipei, Taiwan, Department of Statistics, National Cheng-Kung University, Tainan, Taiwan, School of Public Health, National Defense Medical Center, Taipei, Taiwan

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• Shih-Kai Chu,

  Affiliations Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, Bioinformatics Program, Taiwan International Graduate Program, Institute of Information Science, Academia Sinica, Taipei, Taiwan, Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan

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• Chieh-Liang Huang,

  Affiliations Center for Drug Abuse and Addiction, China Medical University Hospital, Taichung, Taiwan, School of Medicine, China Medical University, Taichung, Taiwan

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• Hsiang-Wei Kuo,

  Affiliation Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan

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• Sheng-Chang Wang,

  Affiliation Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan

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• Sheng-Wen Liu,

  Affiliation Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan

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• Ing-Kang Ho,

  Affiliation Center for Drug Abuse and Addiction, China Medical University Hospital, Taichung, Taiwan

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• Yu-Li Liu

  * E-mail: ylliou@nhri.org.tw

  Affiliations Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan, Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

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