Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization

• Smita Mohanty ,

  Contributed equally to this work with: Smita Mohanty, Krishnadev Oruganty

  Affiliation Department of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia, United States of America

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• Krishnadev Oruganty ,

  Contributed equally to this work with: Smita Mohanty, Krishnadev Oruganty

  Affiliation Department of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia, United States of America

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• Annie Kwon,

  Affiliation Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America

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• Dominic P. Byrne,

  Affiliation Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

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• Samantha Ferries,

  Affiliation Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

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• Zheng Ruan,

  Affiliation Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America

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• Laura E. Hanold,

  Affiliation Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, United States of America

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• Samiksha Katiyar,

  Affiliation Department of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia, United States of America

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• Eileen J. Kennedy,

  Affiliation Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, United States of America

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• Patrick A. Eyers,

  Affiliation Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

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• Natarajan Kannan

  * E-mail: kannan@bmb.uga.edu

  Affiliations Department of Biochemistry & Molecular Biology, University of Georgia, Athens, Georgia, United States of America, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America

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