The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress

Raymond Buser; Vanessa Kellner; Andre Melnik; Caroline Wilson-Zbinden; René Schellhaas; Lisa Kastner; Wojciech Piwko; Martina Dees; Paola Picotti; Marija Maric; Karim Labib; Brian Luke; Matthias Peter

doi:10.1371/journal.pgen.1005843

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Open Access

Peer-reviewed

Research Article

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101^Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress

Raymond Buser ,

Contributed equally to this work with: Raymond Buser, Vanessa Kellner

Affiliation Institute of Biochemistry, Department of Biology, ETH Zurich, Zürich, Switzerland
⨯
Vanessa Kellner ,

Contributed equally to this work with: Raymond Buser, Vanessa Kellner

Current address: Institute of Molecular Biology (IMB), Mainz, Germany

Affiliation Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg, Germany
⨯
Andre Melnik,

Affiliation Institute of Biochemistry, Department of Biology, ETH Zurich, Zürich, Switzerland
⨯
Caroline Wilson-Zbinden,

Affiliation Institute of Biochemistry, Department of Biology, ETH Zurich, Zürich, Switzerland
⨯
René Schellhaas,

Current address: Institute of Molecular Biology (IMB), Mainz, Germany

Affiliation Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg, Germany
⨯
Lisa Kastner,

Affiliation Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg, Germany
⨯
Wojciech Piwko,

Affiliation Institute of Biochemistry, Department of Biology, ETH Zurich, Zürich, Switzerland
⨯
Martina Dees,

Affiliation Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg, Germany
⨯
Paola Picotti,

Affiliation Institute of Biochemistry, Department of Biology, ETH Zurich, Zürich, Switzerland
⨯
Marija Maric,

Affiliation MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
⨯
Karim Labib,

Affiliation MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
⨯
Brian Luke ,

* E-mail: b.luke@imb-mainz.de (BL); matthias.peter@bc.biol.ethz.ch (MP)

Current address: Institute of Molecular Biology (IMB), Mainz, Germany

Affiliation Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg, Germany
⨯
Matthias Peter

* E-mail: b.luke@imb-mainz.de (BL); matthias.peter@bc.biol.ethz.ch (MP)

Affiliation Institute of Biochemistry, Department of Biology, ETH Zurich, Zürich, Switzerland
⨯

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101^Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress

Raymond Buser,
Vanessa Kellner,
Andre Melnik,
Caroline Wilson-Zbinden,
René Schellhaas,
Lisa Kastner,
Wojciech Piwko,
Martina Dees,
Paola Picotti,
Marija Maric

Published: February 5, 2016
https://doi.org/10.1371/journal.pgen.1005843

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