Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

Scott A. Keith; Sarah K. Maddux; Yayu Zhong; Meghna N. Chinchankar; Annabel A. Ferguson; Arjumand Ghazi; Alfred L. Fisher

doi:10.1371/journal.pgen.1005823

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Research Article

Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

Scott A. Keith ,

Contributed equally to this work with: Scott A. Keith, Sarah K. Maddux, Yayu Zhong

Affiliation Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Sarah K. Maddux ,

Contributed equally to this work with: Scott A. Keith, Sarah K. Maddux, Yayu Zhong

Affiliations Division of Geriatrics, Gerontology, and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, United States of America, Center for Healthy Aging, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, United States of America
⨯
Yayu Zhong ,

Contributed equally to this work with: Scott A. Keith, Sarah K. Maddux, Yayu Zhong

Affiliations Division of Geriatrics, Gerontology, and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, United States of America, Center for Healthy Aging, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, United States of America
⨯
Meghna N. Chinchankar,

Affiliations Division of Geriatrics, Gerontology, and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, United States of America, Center for Healthy Aging, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, United States of America
⨯
Annabel A. Ferguson,

Affiliation Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Arjumand Ghazi,

Affiliation Rangos Research Center, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Alfred L. Fisher

* E-mail: fishera2@uthscsa.edu

Affiliations Division of Geriatrics, Gerontology, and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, United States of America, Center for Healthy Aging, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, United States of America, San Antonio GRECC, South Texas VA Healthcare System, San Antonio, Texas, United States of America
⨯

Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

Scott A. Keith,
Sarah K. Maddux,
Yayu Zhong,
Meghna N. Chinchankar,
Annabel A. Ferguson,
Arjumand Ghazi,
Alfred L. Fisher

Published: February 1, 2016
https://doi.org/10.1371/journal.pgen.1005823

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Proteasomes
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RNA interference
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Lysosomes
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Transcription factors
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Fluorescence imaging
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