Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation

• Long Guo,

  Affiliation Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Hiroshi Yamashita,

  Affiliation Department of Molecular Biology and Biochemistry, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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• Ikuyo Kou,

  Affiliation Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan

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• Aki Takimoto,

  Affiliation Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Makiko Meguro-Horike,

  Affiliation Division of Functional Genomics, Advanced Science Research Center, Kanazawa University, Kanazawa, Japan

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• Shin-ichi Horike,

  Affiliation Division of Functional Genomics, Advanced Science Research Center, Kanazawa University, Kanazawa, Japan

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• Tetsushi Sakuma,

  Affiliation Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan

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• Shigenori Miura,

  Affiliation Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Taiji Adachi,

  Affiliation Department of Biomechanics, Research Center for Nano Medical Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Takashi Yamamoto,

  Affiliation Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan

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• Shiro Ikegawa,

  Affiliation Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan

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• Yuji Hiraki,

  Affiliation Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Chisa Shukunami

  * E-mail: shukunam@hiroshima-u.ac.jp

  Affiliations Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, Department of Molecular Biology and Biochemistry, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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