An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies

Wesley K. Thompson; Yunpeng Wang; Andrew J. Schork; Aree Witoelar; Verena Zuber; Shujing Xu; Thomas Werge; Dominic Holland; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Ole A. Andreassen; Anders M. Dale

doi:10.1371/journal.pgen.1005717

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Open Access

Peer-reviewed

Research Article

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies

Wesley K. Thompson ,

* E-mail: wesley.kurt.thompson@regionh.dk

Affiliations Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services, Copenhagen, Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark, Department of Psychiatry, University of California, San Diego, La Jolla, California, United States of America
⨯
Yunpeng Wang,

Affiliation Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
⨯
Andrew J. Schork,

Affiliation Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America
⨯
Aree Witoelar,

Affiliation Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
⨯
Verena Zuber,

Affiliation Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
⨯
Shujing Xu,

Affiliation Department of Psychiatry, University of California, San Diego, La Jolla, California, United States of America
⨯
Thomas Werge,

Affiliations Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services, Copenhagen, Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
⨯
Dominic Holland,

Affiliation Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, California, United States of America
⨯
Schizophrenia Working Group of the Psychiatric Genomics Consortium ,

¶Full membership of Schizophrenia Working Group of the Psychiatric Genomics Consortium is provided in S1 Text.
⨯
Ole A. Andreassen,

Affiliation Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
⨯
Anders M. Dale

Affiliation Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, California, United States of America
⨯

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies

Wesley K. Thompson,
Yunpeng Wang,
Andrew J. Schork,
Aree Witoelar,
Verena Zuber,
Shujing Xu,
Thomas Werge,
Dominic Holland,
Schizophrenia Working Group of the Psychiatric Genomics Consortium,
Ole A. Andreassen

Published: December 29, 2015
https://doi.org/10.1371/journal.pgen.1005717

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