The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish

Ewa Bielczyk-Maczyńska; Laure Lam Hung; Lauren Ferreira; Tobias Fleischmann; Félix Weis; Antonio Fernández-Pevida; Steven A. Harvey; Neha Wali; Alan J. Warren; Inês Barroso; Derek L. Stemple; Ana Cvejic

doi:10.1371/journal.pgen.1005677

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Peer-reviewed

Research Article

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish

Ewa Bielczyk-Maczyńska ,

Contributed equally to this work with: Ewa Bielczyk-Maczyńska, Laure Lam Hung

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom, NHS Blood and Transplant, Cambridge, United Kingdom
⨯
Laure Lam Hung ,

Contributed equally to this work with: Ewa Bielczyk-Maczyńska, Laure Lam Hung

Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Lauren Ferreira,

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Tobias Fleischmann,

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, Cambridge, United Kingdom, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Félix Weis,

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, Cambridge, United Kingdom, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Antonio Fernández-Pevida,

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, Cambridge, United Kingdom, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Steven A. Harvey,

Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Neha Wali,

Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Alan J. Warren,

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, Cambridge, United Kingdom, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Inês Barroso,

Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Derek L. Stemple ,

¶‡ DLS and AC also contributed equally to this work.

Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Ana Cvejic

* E-mail: as889@cam.ac.uk

¶‡ DLS and AC also contributed equally to this work.

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⨯

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish

Ewa Bielczyk-Maczyńska,
Laure Lam Hung,
Lauren Ferreira,
Tobias Fleischmann,
Félix Weis,
Antonio Fernández-Pevida,
Steven A. Harvey,
Neha Wali,
Alan J. Warren,
Inês Barroso

Published: December 1, 2015
https://doi.org/10.1371/journal.pgen.1005677

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