Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain

• Kai Wang ,

  Contributed equally to this work with: Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z. Gong

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America, Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

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• Ruijuan Xu ,

  Contributed equally to this work with: Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z. Gong

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America

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• Jennifer Schrandt ,

  Contributed equally to this work with: Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z. Gong

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America

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• Prithvi Shah ,

  Contributed equally to this work with: Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z. Gong

  Affiliations Division of Rehabilitation Sciences, Department of Physical Therapy, School of Health Technology and Management, Stony Brook University, Stony Brook, New York, United States of America, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, United States of America

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• Yong Z. Gong ,

  Contributed equally to this work with: Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z. Gong

  Affiliation Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Chet Preston,

  Affiliation Division of Rehabilitation Sciences, Department of Physical Therapy, School of Health Technology and Management, Stony Brook University, Stony Brook, New York, United States of America

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• Louis Wang,

  Affiliation Division of Rehabilitation Sciences, Department of Physical Therapy, School of Health Technology and Management, Stony Brook University, Stony Brook, New York, United States of America

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• Jae Kyo Yi,

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America

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• Chih-Li Lin,

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America

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• Wei Sun,

  Affiliation Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Demetri D. Spyropoulos,

  Affiliation Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Soyoung Rhee,

  Affiliation Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Mingsong Li,

  Affiliation Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China

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• Jie Zhou,

  Affiliation Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

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• Shaoyu Ge,

  Affiliation Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Guofeng Zhang,

  Affiliation Biomedical Engineering and Physical Science Shared Resource, National Institute of Biomedical Imaging and Bioengineering, National Institute of Health, Bethesda, Maryland, United States of America

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• Ashley J. Snider,

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America, Northport Veterans Affairs Medical Center, Northport, New York, United States of America

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• Yusuf A. Hannun,

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America

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• Lina M. Obeid,

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America, Northport Veterans Affairs Medical Center, Northport, New York, United States of America

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•  [ ... ],
• Cungui Mao

  * E-mail: cungui.mao@stonybrook.edu.

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, Stony Brook Cancer Center, Stony Brook, New York, United States of America

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