FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores

Elite Possik; Andrew Ajisebutu; Sanaz Manteghi; Marie-Claude Gingras; Tarika Vijayaraghavan; Mathieu Flamand; Barry Coull; Kathrin Schmeisser; Thomas Duchaine; Maurice van Steensel; David H. Hall; Arnim Pause

doi:10.1371/journal.pgen.1005520

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Open Access

Peer-reviewed

Research Article

FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores

Elite Possik,

Affiliations Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada
⨯
Andrew Ajisebutu,

Affiliations Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada
⨯
Sanaz Manteghi,

Affiliations Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada
⨯
Marie-Claude Gingras,

Affiliations Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada
⨯
Tarika Vijayaraghavan,

Affiliations Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada
⨯
Mathieu Flamand,

Affiliation Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada
⨯
Barry Coull,

Affiliation College of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Kathrin Schmeisser,

Affiliations Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada
⨯
Thomas Duchaine,

Affiliations Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada
⨯
Maurice van Steensel,

Affiliations College of Life Sciences, University of Dundee, Dundee, United Kingdom, Institute of Medical Biology, Singapore, Singapore
⨯
David H. Hall,

Affiliation Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, United States of America
⨯
Arnim Pause

* E-mail: arnim.pause@mcgill.ca

Affiliations Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada, Department of Biochemistry, McGill University, Montréal, Québec, Canada
⨯

FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores

Elite Possik,
Andrew Ajisebutu,
Sanaz Manteghi,
Marie-Claude Gingras,
Tarika Vijayaraghavan,
Mathieu Flamand,
Barry Coull,
Kathrin Schmeisser,
Thomas Duchaine,
Maurice van Steensel

Published: October 6, 2015
https://doi.org/10.1371/journal.pgen.1005520

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Renal cancer
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Glycerol
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Caenorhabditis elegans
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