Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood

• Ralph Burkhardt ,

  Contributed equally to this work with: Ralph Burkhardt, Holger Kirsten

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

  ⨯
• Holger Kirsten ,

  Contributed equally to this work with: Ralph Burkhardt, Holger Kirsten

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany, Department for Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany

  ⨯
• Frank Beutner,

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Heart Center Leipzig, Leipzig, Germany

  ⨯
• Lesca M. Holdt,

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute for Laboratory Medicine, Ludwig-Maximilians University Munich, Munich, Germany

  ⨯
• Arnd Gross,

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

  ⨯
• Andrej Teren,

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Heart Center Leipzig, Leipzig, Germany

  ⨯
• Anke Tönjes,

  Affiliation Medical Department, Clinic for Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

  ⨯
• Susen Becker,

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

  ⨯
• Knut Krohn,

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany

  ⨯
• Peter Kovacs,

  Affiliation Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig Germany

  ⨯
• Michael Stumvoll,

  Affiliations Medical Department, Clinic for Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany, Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig Germany

  ⨯
• Daniel Teupser,

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute for Laboratory Medicine, Ludwig-Maximilians University Munich, Munich, Germany

  ⨯
• Joachim Thiery,

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

  ⨯
• Uta Ceglarek ,

  ¶‡ UC and MSc also contributed equally to this work.

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany

  ⨯
• Markus Scholz

  * E-mail: markus.scholz@imise.uni-leipzig.de

  ¶‡ UC and MSc also contributed equally to this work.

  Affiliations LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany, Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

  ⨯