The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway

• Yuzuru Imai ,

  * E-mail: yzimai@juntendo.ac.jp (YI); nhattori@juntendo.ac.jp (NH); ryosuket@kuhp.kyoto-u.ac.jp (RT)

  ¶‡ These authors contributed equally to this work.

  Affiliation Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan

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• Yoshito Kobayashi ,

  ¶‡ These authors contributed equally to this work.

  Affiliations Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, CREST (Core Research for Evolutionary Science and Technology), Japan Science and Technology Agency, Saitama, Japan

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• Tsuyoshi Inoshita,

  Affiliation Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan

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• Hongrui Meng,

  Affiliation Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan

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• Taku Arano,

  Affiliation Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan

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• Kengo Uemura,

  Affiliation Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Takeshi Asano,

  Affiliation Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Kenji Yoshimi,

  Affiliation Department of Neurophysiology, Juntendo University Graduate School of Medicine, Tokyo, Japan

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• Chang-Liang Zhang,

  Affiliations Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, CREST (Core Research for Evolutionary Science and Technology), Japan Science and Technology Agency, Saitama, Japan

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• Gen Matsumoto,

  Affiliation Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan

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• Toshiyuki Ohtsuka,

  Affiliation Department of Cell Biology, Institute for Virus Research, Kyoto University, Kyoto, Japan

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• Ryoichiro Kageyama,

  Affiliation Department of Cell Biology, Institute for Virus Research, Kyoto University, Kyoto, Japan

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• Hiroshi Kiyonari,

  Affiliation Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe, Japan

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• Go Shioi,

  Affiliation Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe, Japan

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• Nobuyuki Nukina,

  Affiliation Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan

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• Nobutaka Hattori ,

  * E-mail: yzimai@juntendo.ac.jp (YI); nhattori@juntendo.ac.jp (NH); ryosuket@kuhp.kyoto-u.ac.jp (RT)

  Affiliations Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan, CREST (Core Research for Evolutionary Science and Technology), Japan Science and Technology Agency, Saitama, Japan, Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan, Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan, Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan

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•  [ ... ],
• Ryosuke Takahashi

  * E-mail: yzimai@juntendo.ac.jp (YI); nhattori@juntendo.ac.jp (NH); ryosuket@kuhp.kyoto-u.ac.jp (RT)

  Affiliations Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, CREST (Core Research for Evolutionary Science and Technology), Japan Science and Technology Agency, Saitama, Japan

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