The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity

• Slavé Petrovski ,

  Contributed equally to this work with: Slavé Petrovski, Ayal B. Gussow

  * E-mail: sp3347@cumc.columbia.edu (SP); dg2875@cumc.columbia.edu (DBG)

  Affiliations Institute for Genomic Medicine, Columbia University, New York, New York, United States of America, Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America, Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria, Australia

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• Ayal B. Gussow ,

  Contributed equally to this work with: Slavé Petrovski, Ayal B. Gussow

  Affiliations Institute for Genomic Medicine, Columbia University, New York, New York, United States of America, Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America, Program in Computational Biology and Bioinformatics, Duke University, Durham, North Carolina, United States of America

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• Quanli Wang,

  Affiliations Institute for Genomic Medicine, Columbia University, New York, New York, United States of America, Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America

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• Matt Halvorsen,

  Affiliations Institute for Genomic Medicine, Columbia University, New York, New York, United States of America, Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America

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• Yujun Han,

  Affiliation Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America

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• William H. Weir,

  Affiliation Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America

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• Andrew S. Allen,

  Affiliations Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America, Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States of America

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• David B. Goldstein

  * E-mail: sp3347@cumc.columbia.edu (SP); dg2875@cumc.columbia.edu (DBG)

  Affiliations Institute for Genomic Medicine, Columbia University, New York, New York, United States of America, Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America

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