Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling

Suresh Marada; Gemma Navarro; Ashley Truong; Daniel P. Stewart; Angela M. Arensdorf; Sigrid Nachtergaele; Edgar Angelats; Joseph T. Opferman; Rajat Rohatgi; Peter J. McCormick; Stacey K. Ogden

doi:10.1371/journal.pgen.1005473

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Open Access

Peer-reviewed

Research Article

Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling

Suresh Marada,

Affiliation Department of Cell & Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Gemma Navarro,

Affiliation Department of Biochemistry and Molecular Biology, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)University of Barcelona, Barcelona, Spain
⨯
Ashley Truong,

Affiliations Department of Cell & Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Summer Plus Program, Rhodes College, Memphis, Tennessee, United States of America
⨯
Daniel P. Stewart,

Affiliation Department of Cell & Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Angela M. Arensdorf,

Affiliation Department of Cell & Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Sigrid Nachtergaele,

Affiliation Departments of Medicine and Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Edgar Angelats,

Affiliation Department of Biochemistry and Molecular Biology, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)University of Barcelona, Barcelona, Spain
⨯
Joseph T. Opferman,

Affiliation Department of Cell & Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Rajat Rohatgi,

Affiliation Departments of Medicine and Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Peter J. McCormick,

Affiliations Department of Biochemistry and Molecular Biology, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)University of Barcelona, Barcelona, Spain, School of Pharmacy, University of East Anglia, Norwich, Norfolk, United Kingdom
⨯
Stacey K. Ogden

* E-mail: Stacey.Ogden@stjude.org

Affiliation Department of Cell & Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯

Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling

Suresh Marada,
Gemma Navarro,
Ashley Truong,
Daniel P. Stewart,
Angela M. Arensdorf,
Sigrid Nachtergaele,
Edgar Angelats,
Joseph T. Opferman,
Rajat Rohatgi,
Peter J. McCormick

Published: August 20, 2015
https://doi.org/10.1371/journal.pgen.1005473

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Hedgehog signaling
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G-protein signaling
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Drosophila melanogaster
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