YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Claudia Stein; Anaïs Flore Bardet; Guglielmo Roma; Sebastian Bergling; Ieuan Clay; Alexandra Ruchti; Claudia Agarinis; Tobias Schmelzle; Tewis Bouwmeester; Dirk Schübeler; Andreas Bauer

doi:10.1371/journal.pgen.1005465

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Open Access

Peer-reviewed

Research Article

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Claudia Stein ,

Contributed equally to this work with: Claudia Stein, Anaïs Flore Bardet

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Anaïs Flore Bardet ,

Contributed equally to this work with: Claudia Stein, Anaïs Flore Bardet

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
⨯
Guglielmo Roma,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
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Sebastian Bergling,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
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Ieuan Clay,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
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Alexandra Ruchti,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
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Claudia Agarinis,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
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Tobias Schmelzle,

Affiliation Oncology, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
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Tewis Bouwmeester,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
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Dirk Schübeler ,

* E-mail: dirk.schubeler@fmi.ch (DS); andreas-1.bauer@novartis.com (AB)

Affiliations Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, University of Basel, Faculty of Sciences, Basel, Switzerland
⨯
Andreas Bauer

* E-mail: dirk.schubeler@fmi.ch (DS); andreas-1.bauer@novartis.com (AB)

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
⨯

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Claudia Stein,
Anaïs Flore Bardet,
Guglielmo Roma,
Sebastian Bergling,
Ieuan Clay,
Alexandra Ruchti,
Claudia Agarinis,
Tobias Schmelzle,
Tewis Bouwmeester,
Dirk Schübeler

Published: August 21, 2015
https://doi.org/10.1371/journal.pgen.1005465

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Small interfering RNA
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Cell binding
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Chromatin
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Gene regulation
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Transcriptional control
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