In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11

• Rita-Eva Varga ,

  ¶‡ These authors share first authorship on this work.

  Affiliations Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany, Institute of Clinical Chemistry, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Mukhran Khundadze ,

  ¶‡ These authors share first authorship on this work.

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Markus Damme,

  Affiliation Biochemical Institute, University of Kiel, Kiel, Germany

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• Sandor Nietzsche,

  Affiliation Electron Microscopy Center, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Birgit Hoffmann,

  Affiliation Biomolecular Photonics Group, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Tobias Stauber,

  Current Address: Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany

  Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP) und Max-Delbrück Centrum für Molekulare Medizin (MDC), Berlin, Germany

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• Nicole Koch,

  Affiliation Institute of Biochemistry I, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• J. Christopher Hennings,

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Patricia Franzka,

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Antje K. Huebner,

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Michael M. Kessels,

  Affiliation Institute of Biochemistry I, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Christoph Biskup,

  Affiliation Biomolecular Photonics Group, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Thomas J. Jentsch,

  Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP) und Max-Delbrück Centrum für Molekulare Medizin (MDC), Berlin, Germany

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• Britta Qualmann,

  Affiliation Institute of Biochemistry I, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Thomas Braulke,

  Affiliation Department of Biochemistry, Children’s Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Ingo Kurth,

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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• Christian Beetz,

  Affiliation Institute of Clinical Chemistry, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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•  [ ... ],
• Christian A. Hübner

  * E-mail: christian.huebner@med.uni-jena.de

  Affiliation Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany

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