BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma

• Daniel Nettersheim,

  Affiliation Institute of Pathology, Department of Developmental Pathology, University Medical School, Bonn, Germany

  ⨯
• Sina Jostes,

  Affiliation Institute of Pathology, Department of Developmental Pathology, University Medical School, Bonn, Germany

  ⨯
• Rakesh Sharma,

  Affiliation Institute of Pathology, Department of Developmental Pathology, University Medical School, Bonn, Germany

  ⨯
• Simon Schneider,

  Affiliation Institute of Pathology, Department of Developmental Pathology, University Medical School, Bonn, Germany

  ⨯
• Andrea Hofmann,

  Affiliation Institute of Human Genetics, University Medical School, Bonn, Germany

  ⨯
• Humberto J. Ferreira,

  Affiliation Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute, L’Hospitalet, Barcelona, Catalonia, Spain

  ⨯
• Per Hoffmann,

  Affiliation Institute of Human Genetics, University Medical School, Bonn, Germany

  ⨯
• Glen Kristiansen,

  Affiliation Institute of Pathology, University Medical School, Bonn, Germany

  ⨯
• Manel B. Esteller,

  Affiliations Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute, L’Hospitalet, Barcelona, Catalonia, Spain, Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain, Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain

  ⨯
• Hubert Schorle

  * E-mail: Hubert.Schorle@ukb.uni-bonn.de

  Affiliation Institute of Pathology, Department of Developmental Pathology, University Medical School, Bonn, Germany

  ⨯