A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease

• Solveig Gretarsdottir ,

  Contributed equally to this work with: Solveig Gretarsdottir, Hannes Helgason

  Affiliation deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

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• Hannes Helgason ,

  Contributed equally to this work with: Solveig Gretarsdottir, Hannes Helgason

  Affiliations deCODE Genetics/Amgen, Inc., Reykjavik, Iceland, School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland

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• Anna Helgadottir,

  Affiliations deCODE Genetics/Amgen, Inc., Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Asgeir Sigurdsson,

  Affiliation deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

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• Gudmar Thorleifsson,

  Affiliation deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

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• Audur Magnusdottir,

  Affiliation deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

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• Asmundur Oddsson,

  Affiliation deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

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• Valgerdur Steinthorsdottir,

  Affiliation deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

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• Thorunn Rafnar,

  Affiliation deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

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• Jacqueline de Graaf,

  Affiliation Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands

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• Maryam S. Daneshpour,

  Affiliation Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran

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• Mehdi Hedayati,

  Affiliation Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran

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• Fereidoun Azizi,

  Affiliation Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran

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• Niels Grarup,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Torben Jørgensen,

  Affiliations Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark, Faculty of Medicine, University of Aalborg, Aalborg, Denmark, Institute of Public Health and Medical Science, University of Copenhagen, Copenhagen, Denmark

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• Henrik Vestergaard,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Torben Hansen,

  Affiliations The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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• Gudmundur Eyjolfsson,

  Affiliation The Laboratory in Mjodd, RAM, Reykjavik, Iceland

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• Olof Sigurdardottir,

  Affiliation Department of Clinical Biochemistry, Akureyri Hospital, Akureyri, Iceland

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• Isleifur Olafsson,

  Affiliation Department of Clinical Biochemistry, Landspitali, National University Hospital, Reykjavik, Iceland

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• Lambertus A. Kiemeney,

  Affiliation Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands

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• Oluf Pedersen,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Patrick Sulem,

  Affiliation deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

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• Gudmundur Thorgeirsson,

  Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Division of Cardiology, Department of Internal Medicine, Landspitali, National University Hospital of Iceland, Reykjavik, Iceland

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• Daniel F. Gudbjartsson,

  Affiliations deCODE Genetics/Amgen, Inc., Reykjavik, Iceland, School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland

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• Hilma Holm,

  Affiliations deCODE Genetics/Amgen, Inc., Reykjavik, Iceland, Division of Cardiology, Department of Internal Medicine, Landspitali, National University Hospital of Iceland, Reykjavik, Iceland

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• Unnur Thorsteinsdottir ,

  * E-mail: unnur.thorsteinsdottir@decode.is (UT); kstefans@decode.is (KS)

  Affiliations deCODE Genetics/Amgen, Inc., Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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•  [ ... ],
• Kari Stefansson

  * E-mail: unnur.thorsteinsdottir@decode.is (UT); kstefans@decode.is (KS)

  Affiliations deCODE Genetics/Amgen, Inc., Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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