SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation

Siqi Hu; Jian Li; Fengwen Xu; Shan Mei; Yann Le Duff; Lijuan Yin; Xiaojing Pang; Shan Cen; Qi Jin; Chen Liang; Fei Guo

doi:10.1371/journal.pgen.1005367

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Open Access

Peer-reviewed

Research Article

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation

Siqi Hu ,

Contributed equally to this work with: Siqi Hu, Jian Li

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Jian Li ,

Contributed equally to this work with: Siqi Hu, Jian Li

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Fengwen Xu,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Shan Mei,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Yann Le Duff,

Affiliation Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
⨯
Lijuan Yin,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Xiaojing Pang,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Shan Cen,

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Qi Jin ,

* E-mail: zdsys@vip.sina.com (QJ); chen.liang@mcgill.ca (CL); guoafei@hotmail.com (FG)

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Chen Liang ,

* E-mail: zdsys@vip.sina.com (QJ); chen.liang@mcgill.ca (CL); guoafei@hotmail.com (FG)

Affiliation Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
⨯
Fei Guo

* E-mail: zdsys@vip.sina.com (QJ); chen.liang@mcgill.ca (CL); guoafei@hotmail.com (FG)

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation

Siqi Hu,
Jian Li,
Fengwen Xu,
Shan Mei,
Yann Le Duff,
Lijuan Yin,
Xiaojing Pang,
Shan Cen,
Qi Jin,
Chen Liang

Published: July 2, 2015
https://doi.org/10.1371/journal.pgen.1005367

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