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Open Access
Peer-reviewed
Research Article
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
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Julie Guillermet-Guibert ,
* E-mail: julie.guillermet@inserm.fr (JGG); bart.vanh@ucl.ac.uk (BV)
Affiliations UCL Cancer Institute, University College London, London, United Kingdom, Centre de Recherche en Cancérologie de Toulouse UMR1037, INSERM, BP84225, Toulouse, France, Université Toulouse III-Paul Sabatier, Toulouse, France
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Lee B. Smith,
Affiliation MRC Centre for Reproductive Health, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, United Kingdom
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Guillaume Halet,
Affiliations CNRS, UMR 6290, Institut de Génétique et Développement de Rennes, Rennes, France, Université Rennes 1, UEB, SFR BIOSIT UMS 3480, Faculté de Médecine, Rennes, France
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Maria A. Whitehead,
Affiliation UCL Cancer Institute, University College London, London, United Kingdom
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Wayne Pearce,
Affiliation UCL Cancer Institute, University College London, London, United Kingdom
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Diane Rebourcet,
Affiliation MRC Centre for Reproductive Health, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, United Kingdom
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Kelly León,
Affiliation Physiologie de la Reproduction et des Comportements, UMR 7247 INRA—CNRS—Université de Tours, Nouzilly, France
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Pascale Crépieux,
Affiliation Physiologie de la Reproduction et des Comportements, UMR 7247 INRA—CNRS—Université de Tours, Nouzilly, France
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Gemma Nock,
Affiliation UCL Cancer Institute, University College London, London, United Kingdom
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Maria Strömstedt,
Affiliation Astra Zeneca, Research and Development, Mölndal, Mölndal, Sweden
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Malin Enerback,
Affiliation Astra Zeneca, Research and Development, Mölndal, Mölndal, Sweden
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Claude Chelala,
Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom
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Mariona Graupera,
Affiliations UCL Cancer Institute, University College London, London, United Kingdom, Vascular Signalling Laboratory, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), Gran Via de l’Hospitalet 199–203, 08908 L´Hospitalet de Llobregat, Barcelona, Spain
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John Carroll,
Affiliation Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia
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Sabina Cosulich,
Affiliation Astrazeneca Oncology iMED, Alderley Park, Macclesfield, Cheshire, United Kingdom
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Philippa T. K. Saunders,
Affiliation MRC Centre for Inflammation Research, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, United Kingdom
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Ilpo Huhtaniemi ,
¶‡ These authors are joint senior authors on this work.
Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom, and Department of Physiology, University of Turku, Turku, Finland
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Bart Vanhaesebroeck
* E-mail: julie.guillermet@inserm.fr (JGG); bart.vanh@ucl.ac.uk (BV)
¶‡ These authors are joint senior authors on this work.
Affiliation UCL Cancer Institute, University College London, London, United Kingdom
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Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
- Julie Guillermet-Guibert,
- Lee B. Smith,
- Guillaume Halet,
- Maria A. Whitehead,
- Wayne Pearce,
- Diane Rebourcet,
- Kelly León,
- Pascale Crépieux,
- Gemma Nock,
- Maria Strömstedt
- Published: July 1, 2015
- https://doi.org/10.1371/journal.pgen.1005304