In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency

Marina E. Tourlakis; Siyi Zhang; Heather L. Ball; Rikesh Gandhi; Hongrui Liu; Jian Zhong; Julie S. Yuan; Cynthia J. Guidos; Peter R. Durie; Johanna M. Rommens

doi:10.1371/journal.pgen.1005288

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Open Access

Peer-reviewed

Research Article

In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency

Marina E. Tourlakis,

Affiliations Program in Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada
⨯
Siyi Zhang,

Affiliations Program in Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada
⨯
Heather L. Ball,

Affiliation Program in Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada
⨯
Rikesh Gandhi,

Affiliation Program in Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada
⨯
Hongrui Liu,

Affiliations Program in Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada
⨯
Jian Zhong,

Affiliation Program in Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada
⨯
Julie S. Yuan,

Affiliation Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Department of Immunology, University of Toronto, Toronto, Canada
⨯
Cynthia J. Guidos,

Affiliation Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Department of Immunology, University of Toronto, Toronto, Canada
⨯
Peter R. Durie,

Affiliation Program in Physiology & Experimental Medicine, Research Institute, Division of Gastroenterology & Nutrition, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Canada
⨯
Johanna M. Rommens

* E-mail: jrommens@sickkids.ca

Affiliations Program in Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada
⨯

In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency

Marina E. Tourlakis,
Siyi Zhang,
Heather L. Ball,
Rikesh Gandhi,
Hongrui Liu,
Jian Zhong,
Julie S. Yuan,
Cynthia J. Guidos,
Peter R. Durie,
Johanna M. Rommens

Published: June 9, 2015
https://doi.org/10.1371/journal.pgen.1005288

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Apoptosis
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