Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis

• Mary J. Emond ,

  * E-mail: emond@u.washington.edu (MJE); mbamshad@u.washington.edu (MJB)

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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• Tin Louie,

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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• Julia Emerson,

  Affiliations Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Center for Clinical and Translational Medicine, Seattle Children’s Research Institute Seattle, Washington, United States of America

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• Jessica X. Chong,

  Affiliation Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

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• Rasika A. Mathias,

  Affiliation Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Michael R. Knowles,

  Affiliation Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Mark J. Rieder,

  Affiliation Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Holly K. Tabor,

  Affiliations Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Trueman-Katz Center for Pediatric Bioethics, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Debbie A. Nickerson,

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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• Kathleen C. Barnes,

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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• NHLBI GO Exome Sequencing Project ,

  ¶A full list of members and affiliations is provided in the supporting material.

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• Lung GO ,

  ¶A full list of members and affiliations is provided in the supporting material.

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• Ronald L. Gibson,

  Affiliations Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Division of Pulmonary Medicine, Seattle Children’s Hospital, Seattle, Washington, United States of America

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• Michael J. Bamshad

  * E-mail: emond@u.washington.edu (MJE); mbamshad@u.washington.edu (MJB)

  Affiliations Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Division of Genetic Medicine, Seattle Children’s Hospital, Seattle, Washington, United States of America

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