The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding

Xin Xie; Michael J. T. Stubbington; Jesper K. Nissen; Kristian G. Andersen; Daniel Hebenstreit; Sarah A. Teichmann; Alexander G. Betz

doi:10.1371/journal.pgen.1005251

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Peer-reviewed

Research Article

The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding

Xin Xie ,

Contributed equally to this work with: Xin Xie, Michael J. T. Stubbington, Jesper K. Nissen

¶‡ These authors are joint senior authors on this work.

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Michael J. T. Stubbington ,

Contributed equally to this work with: Xin Xie, Michael J. T. Stubbington, Jesper K. Nissen

¶‡ These authors are joint senior authors on this work.

Affiliation European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
⨯
Jesper K. Nissen ,

Contributed equally to this work with: Xin Xie, Michael J. T. Stubbington, Jesper K. Nissen

¶‡ These authors are joint senior authors on this work.

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Kristian G. Andersen,

Current address: Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, and Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Daniel Hebenstreit,

Current address: University of Warwick, Coventry, United Kingdom

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Sarah A. Teichmann,

Affiliation European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
⨯
Alexander G. Betz

* E-mail: betz@mrc-lmb.cam.ac.uk

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯

The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding

Xin Xie,
Michael J. T. Stubbington,
Jesper K. Nissen,
Kristian G. Andersen,
Daniel Hebenstreit,
Sarah A. Teichmann,
Alexander G. Betz

Published: June 24, 2015
https://doi.org/10.1371/journal.pgen.1005251

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Gene expression
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Gene regulation
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Regulatory T cells
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T cells
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Cell staining
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Immunoprecipitation
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Transcriptome analysis
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