Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease

• Maria Wilbe ,

  Contributed equally to this work with: Maria Wilbe, Sergey V. Kozyrev

  Current address: Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

  Affiliation Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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• Sergey V. Kozyrev ,

  Contributed equally to this work with: Maria Wilbe, Sergey V. Kozyrev

  Affiliation Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

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• Fabiana H. G. Farias,

  Affiliation Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

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• Hanna D. Bremer,

  Affiliation Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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• Anna Hedlund,

  Affiliation Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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• Gerli R. Pielberg,

  Affiliation Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

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• Eija H. Seppälä,

  Current address: Blueprint Genetics Ltd, Helsinki, Finland

  Affiliation Research Programs Unit, Molecular Neurology; Department of Veterinary Biosciences, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland

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• Ulla Gustafson,

  Affiliation Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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• Hannes Lohi,

  Affiliation Research Programs Unit, Molecular Neurology; Department of Veterinary Biosciences, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland

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• Örjan Carlborg,

  Affiliation Department of Clinical Sciences, Division of Computational Genetics, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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• Göran Andersson,

  Affiliation Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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• Helene Hansson-Hamlin ,

  * E-mail: helene.hamlin@slu.se (HHH); kersli@broadinstitute.org (KLT)

  ¶‡ HHH and KLT share senior authorship.

  Affiliation Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden

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• Kerstin Lindblad-Toh

  * E-mail: helene.hamlin@slu.se (HHH); kersli@broadinstitute.org (KLT)

  ¶‡ HHH and KLT share senior authorship.

  Affiliations Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden, Broad Institute, Cambridge, Cambridge, Massachusetts, United States of America

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