Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature

Leah Cushing; Stefan Costinean; Wei Xu; Zhihua Jiang; Lindsey Madden; Pingping Kuang; Jingshu Huang; Alexandra Weisman; Akiko Hata; Carlo M. Croce; Jining Lü

doi:10.1371/journal.pgen.1005238

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Open Access

Peer-reviewed

Research Article

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature

Leah Cushing ,

Contributed equally to this work with: Leah Cushing, Stefan Costinean

Affiliation Boston University School of Medicine, Boston, Massachusetts, United States of America
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Stefan Costinean ,

Contributed equally to this work with: Leah Cushing, Stefan Costinean

Affiliation Department of Pathology, Ohio State Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Wei Xu,

Affiliation Columbia Center for Human Development, Division of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America
⨯
Zhihua Jiang,

Affiliation Boston University School of Medicine, Boston, Massachusetts, United States of America
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Lindsey Madden,

Affiliation Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Pingping Kuang,

Affiliation Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Jingshu Huang,

Affiliation Columbia Center for Human Development, Division of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America
⨯
Alexandra Weisman,

Affiliation Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, United States of America
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Akiko Hata,

Affiliations Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, United States of America, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, United States of America
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Carlo M. Croce,

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
⨯
Jining Lü

* E-mail: jl4211@cumc.columbia.edu

Affiliation Columbia Center for Human Development, Division of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, New York, United States of America
⨯

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature

Leah Cushing,
Stefan Costinean,
Wei Xu,
Zhihua Jiang,
Lindsey Madden,
Pingping Kuang,
Jingshu Huang,
Alexandra Weisman,
Akiko Hata,
Carlo M. Croce

Published: May 28, 2015
https://doi.org/10.1371/journal.pgen.1005238

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Lung development
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MicroRNAs
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RNA sequencing
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Cell differentiation
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Gene expression
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Pulmonary arteries
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