The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

Lydia M. Castelli; David Talavera; Christopher J. Kershaw; Sarah S. Mohammad-Qureshi; Joseph L. Costello; William Rowe; Paul F. G. Sims; Christopher M. Grant; Simon J. Hubbard; Mark P. Ashe; Graham D. Pavitt

doi:10.1371/journal.pgen.1005233

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Open Access

Peer-reviewed

Research Article

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

Lydia M. Castelli,

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
David Talavera,

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Christopher J. Kershaw,

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Sarah S. Mohammad-Qureshi,

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Joseph L. Costello,

Current address: Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
William Rowe,

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Paul F. G. Sims,

Affiliations The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom, Manchester Institute of Biotechnology (MIB), The University of Manchester, Manchester, United Kingdom
⨯
Christopher M. Grant,

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Simon J. Hubbard,

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Mark P. Ashe,

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Graham D. Pavitt

* E-mail: graham.pavitt@manchester.ac.uk

Affiliation The Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

Lydia M. Castelli,
David Talavera,
Christopher J. Kershaw,
Sarah S. Mohammad-Qureshi,
Joseph L. Costello,
William Rowe,
Paul F. G. Sims,
Christopher M. Grant,
Simon J. Hubbard,
Mark P. Ashe

Published: May 14, 2015
https://doi.org/10.1371/journal.pgen.1005233

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Messenger RNA
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Ribosomes
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3' UTR
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Protein translation
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Polyribosomes
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Sequence motif analysis
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